The NOTE Pilot Study

The NOTE (Novel Treatments for Endometriosis) Pilot Study was a 6-month clinical trial sponsored by the Boston Center for Endometriosis. We compared the effects of a non-hormonal medication versus a commonly used endometriosis medication for treatment of endometriosis pain. Women 15-40 years old who have had surgery for endometriosis in the last 2 years were eligible to participate.

This study is not currently recruiting. For additional information, please email

The NOTE multi-site study is recruiting.

Research results were published in F&S Reports:

DiVasta AD, Stamoulis C, Gallagher JS, Laufer MR, Anchan R, Hornstein MD. Nonhormonal therapy for endometriosis: a randomized, placebo-controlled, pilot study of cabergoline versus norethindrone acetate. F S Rep. 2021 Jul 24;2(4):454-461. doi: 10.1016/j.xfre.2021.07.003. PMID: 34934987; PMCID: PMC8655411.