The SAGE Trial

Supplementation in Adolescent Girls with Endometriosis (The SAGE Study) was a six-month research study that explored the effect of nutrition on the development and severity of the symptoms of endometriosis. Participants took 2 pills every day (dietary supplement or a placebo pill) to help us study whether these supplements help improved pain and other endometriosis symptoms.

This study is not currently recruiting. For additional information, please email

Research results were published in the American Journal of Clinical Nutrition:

Nodler JL, DiVasta ADVitonis AF, Karevicius S, Malsch M, Sarda V, Fadayomi A, Harris HR, Missmer SA. Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2020 Jul 1;112(1):229-236. doi: 10.1093/ajcn/nqaa096. PMID: 32453393; PMCID: PMC7326593.