The SAGE Trial

Supplementation in Adolescent Girls with Endometriosis (The SAGE Study) was a six-month research study that explored the effect of nutrition on the development and severity of the symptoms of endometriosis. Participants took 2 pills every day (dietary supplement or a placebo pill) to help us study whether these supplements help improved pain and other endometriosis symptoms.

This study is not currently recruiting. For additional information, please email bce@childrens.harvard.edu.

Research results were published in the American Journal of Clinical Nutrition:

Nodler JL, DiVasta AD, Vitonis AF, Karevicius S, Malsch M, Sarda V, Fadayomi A, Harris HR, Missmer SA. Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2020 Jul 1;112(1):229-236. doi: 10.1093/ajcn/nqaa096. PMID: 32453393; PMCID: PMC7326593.  https://academic.oup.com/ajcn/article-abstract/112/1/229/5846052?redirectedFrom=fulltext